A $2.9 million National Cancer Institute grant will support Indiana University School of Medicine research into some of the negative side effects of chemotherapy. Pediatric Oncology Professor Mark Kelley was awarded the funding to investigate chemotherapy-induced neuropathy, which currently has no effective treatment or prevention.
Previous efforts by Kelley and colleagues have shown some promise. "We hypothesize that APE1 is a critical protein for protecting neurons from cancer therapies and that augmenting its DNA repair activity will prevent and reverse chemotherapy-induced alterations in sensory neuronal function," he said. In the lab and in mice, IU says past studies have shown that boosting APE1 protein repair levels decreases neurotoxicity.
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