IU School of Medicine Physician Receives DOD Grant

Posted: Updated:
INDIANAPOLIS -

Treatment responses for patients with metastatic bone cancer are the focus of work that has garnered an IU endocrinologist a $1.2 million Department of Defense grant. Theresa Guise will use the funding to try to understand several events that decrease quality of life for patients being treated for the disease.

Guise wants to find the role of the cellular environment of the tumor-bone on the patients ability to metabolize glucose and how a high-fat diet plays a part. 

“One of the reasons we are studying high-fat diets in mice is to mimic our population in Indiana,” Guise said. “It is known that once cancer is in the bone, it causes bone destruction and the risk of fracture is increased. Diabetes also increases the risk for bone fractures. Our recent data show that bone destruction in the setting of a high-fat diet can induce diabetes. We believe this high glucose load can further impair bone quality, leading to a downward spiral.”

The initial phase of the study will look into older mice with breast cancer that had spread to the bone. The research will determine insulin secretion, bone loss and other factors when they are fed a high-fat or low-fat diet. Another phase of the study will investigate ways to stabilize glucose metabolism in obese mice who have metastatic bone cancer to try to prevent changes that produce diabetes. Data from these two phases will be used with information from breast cancer patients where the disease has spread into the bone to study similarities in the "molecular cascade" that often leads to higher risk of fractures. 

“All three arms of the study will also determine how much fat gets into the bone, blood and other organs and if blocking a specific protein called TGF-beta will interfere with the molecular cascade that causes patients to develop diabetes. TGF-beta is released from the bone during the process of bone breakdown from cancer or cancer treatment. Ideally, the next step will be clinical studies in humans with breast cancer,” Guise said.

Guise is the Jerry and Peggy Throgmorton Professor of Oncology and a co-leader of the Tumor Microenvironment and Metastasis program at IU Melvin and Bren Simon Cancer Center. 

  • Perspectives

    • What Makes Up Quality of Place?

      Economic development is a hot topic these days. With the economy continuing to chug along in robust fashion and unemployment approaching historic lows, communities are refining their objectives and priorities to eek every drop of benefit they can from these financially strong times. Nowhere is this focus greater than with “quality of place,” As cities and states think about how they can distinguish themselves from their peers, a common starting point is developing a...

    More

Subscribe

Name:
Company Name:
Email:
Confirm Email:
HTML
INside Edge
Morning Briefing
BigWigs & New Gigs
Life Sciences Indiana
Indiana Connections
INPower
Subscribe
Unsubscribe

Events



  • Most Popular Stories

    • Ball State Approves Room And Board Increase

      Ball State University trustees have approved a 1.6 percent room and board increase for the 2018-2019 academic year. President Geoffrey Mearns says the increase keeps the school's costs competitive while allowing it to provide modern residence halls to attract and retain top students. The average cost to live on campus for the 2017-2018 academic year is $10,032, which the school says is about $500 less than average for peer and ins-state institutions.

    • 'Fresh Energy' Keeps Bloomington Indie Music Label Moving

      After more than 20 years, a Bloomington-based music label is continuing with its mission of showcasing the independent music scene locally and globally. Secretly Group, which includes the Secretly Canadian, Dean Oceans, Jagjaguwar and The Numero Group labels, has worked over the years with artists including Grammy-winner Bon Ivar, Major Lazer, Yoko Ono and Dinosaur Jr. It has grown to include the labels, a distribution business and a presence in New York, Chicago, Austin...

    • The Amazon Effect: How Big is The Economic Impact?

      Jeff Bezos, CEO of Amazon, increased his net worth by $6.44 billion dollars just by saying a few words. He announced the company's earnings on October 26, 2017, and Amazon stock jumped 8 percent. How are you impacted by the Amazon Effect?

    • (Image courtesy of Pat McAfee Show 2.0)

      Pat McAfee Leaves Barstool

      Less than a year after announcing its launch, former Indianapolis Colts punter-turned-media personality Pat McAfee has exited Barstool Sports. McAfee helped launch Indianapolis-based affiliate Barstool Heartland with Barstool Sports founder Dave Portnoy, but said on his own, independent podcast that he's quitting and has not made plans for his next steps. During the first edition of "The Pat McAfee Show 2.0," McAfee said dealing with the business side...

    • St. Vincent Names Manas Regional President

      Julie Manas has been selected to serve as regional president of the St. Vincent North Region, which includes St. Vincent Anderson, Carmel, Fishers, Kokomo, Mercy, Randolph and Williamsport hospitals. She has more than 30 years of healthcare experience and most recently comes from Hospital Sisters Health System, Western Wisconsin Division, where she held the role of president and chief executive officer.