Millions Awarded to IU Cancer Researchers

Posted: Updated:
INDIANAPOLIS -

The work to lessen the side effects of chemotherapy by some Indiana University cancer researchers has received a big boost. Jill Fehrenbacher and Mark Kelley are the recipients of a five-year $2.3 million National Cancer Institute grant.

They will test the effectiveness of a targeted molecule to prevent or reverse chemotheraphy-induced peripheral neuropathy, or CIPN, caused by various cancer drugs in mice with tumors. 

“For patients with CIPN, this might be an option for pain relief or neuropathic symptom relief in the future,” said Fehrenbacher, associate professor of pharmacology and toxicology at IU School of Medicine. “Alternatively, for patients undergoing chemotherapy treatments, it might be something we can administer alongside the chemotherapy drugs so they never develop CIPN.”

Neuropathy is severe enough for some patients to stop chemotherapy treatments, with the effects lingering beyond the treatment course. No effective treatments are currently available because researchers don't exactly know the cause. Researchers do believe neuropathy develops over time and alters the function of neurons that detect pain and touch. 

Kelley is associate director of basic science research at the IU Simon Cancer Center and was awarded a nearly $3M grant to study CIPN in 2017, and developed a drug found to be effective in reducing a protein's ability to spread tumors in some mice. APX3330 is the culmination of Kelley's nearly three decades of research, and is now in phase 1 trials by Apexian Pharmaceuticals. 

  • Perspectives

    • When The Lights Go Out For Large Retail Spaces, How Do You Create a New Land of Opportunity?

      Another day, another retail giant is closing their stores.  As of early April 2019, over 5,900 store closures in the United States were announced according to Coresight Research. 2018 saw over 5,500 closures with 2017 setting the record with 8,139 closures. Debate abounds on what brought down the once popular shopping mall. The internet and ecommerce?  Millennial buying habits? The resurgence of downtown living and re-urbanization?

    More

Subscribe

Name:
Company Name:
Email:
Confirm Email:
HTML
INside Edge
Morning Briefing
BigWigs & New Gigs
Life Sciences Indiana
Indiana Connections
INPower
Subscribe
Unsubscribe

Events



  • Most Popular Stories

    • (photo courtesy of Pac-Van)

      Pac-Van Makes Another Acquisition

      Indianapolis-based Pac-Van Inc. is once again adding to its portfolio. The storage and office space provider has acquired the assets of Kentucky-based Pier Mobile Storage, though financial terms of the deal were not disclosed.

    • (photo courtesy Parkview Health)

      Hoosier Hospitals Among 'Best Places to Work in Healthcare'

      Seven Indiana hospitals are featured on Modern Healthcare’s list of Best Places to Work in Healthcare. The publication says honorees on the list were selected for their ability to “stand out in their efforts to create an empowered and satisfied workforce.” 

    • Photo courtesy of Portillo's

      Portillo's to Open Fort Wayne Location

      Portillo's Restaurant has announced it will open a new 7,800-square-foot restaurant in Fort Wayne. The location will be near the Glenbrook Square Mall and is slated to open in late 2019. 

    • Greenwood Mayor Mark Myers

      Mayor: Cummins Project Will Have 'Huge Impact'

      The mayor of Greenwood says a planned investment from Columbus-based Cummins Inc. (NYSE: CMI) for a new office in the Johnson County city will have a huge impact. The engine manufacturer announced Thursday it is investing $35 million to construct an digital and information technology hub near I-65 and County Line Road, which will house some 500 workers, with many earning six-figure salaries. In an interview with Inside INdiana Business Reporter Mary-Rachel Redman...

    • (photo courtesy of Reid Health)

      Reid Health To Acquire Fayette Regional Health System

      Reid Health has entered into an agreement to acquire the assets of Fayette Regional Health System of Connersville. The announcement comes after Fayette Regional filed for protection under Chapter 11 in October 2018. Specific terms will be disclosed in the bankruptcy case and will include a $12.75M payment to the bankruptcy estate of Fayette. The deal requires bankruptcy and regulatory approval and is expected to be finalized in mid-July this year.