Millions Awarded to IU Cancer Researchers

Posted: Updated:
INDIANAPOLIS -

The work to lessen the side effects of chemotherapy by some Indiana University cancer researchers has received a big boost. Jill Fehrenbacher and Mark Kelley are the recipients of a five-year $2.3 million National Cancer Institute grant.

They will test the effectiveness of a targeted molecule to prevent or reverse chemotheraphy-induced peripheral neuropathy, or CIPN, caused by various cancer drugs in mice with tumors. 

“For patients with CIPN, this might be an option for pain relief or neuropathic symptom relief in the future,” said Fehrenbacher, associate professor of pharmacology and toxicology at IU School of Medicine. “Alternatively, for patients undergoing chemotherapy treatments, it might be something we can administer alongside the chemotherapy drugs so they never develop CIPN.”

Neuropathy is severe enough for some patients to stop chemotherapy treatments, with the effects lingering beyond the treatment course. No effective treatments are currently available because researchers don't exactly know the cause. Researchers do believe neuropathy develops over time and alters the function of neurons that detect pain and touch. 

Kelley is associate director of basic science research at the IU Simon Cancer Center and was awarded a nearly $3M grant to study CIPN in 2017, and developed a drug found to be effective in reducing a protein's ability to spread tumors in some mice. APX3330 is the culmination of Kelley's nearly three decades of research, and is now in phase 1 trials by Apexian Pharmaceuticals. 

  • Perspectives

    • Amazon HQ2 Decision Should Prompt Reflection on State, Local Strategies

      All great leaders I've learned from have emphasized the importance of questioning norms. Why do we do this? Why do we do it that way? As times change, the things we do and the ways in which we do them should reflect those changing conditions. The fact that Indiana was unable to make the final cut for Amazon’s multi-faceted HQ2 mega project when it boasts the 10th-best business climate should cause leaders to pause and ask...

    More

Subscribe

Name:
Company Name:
Email:
Confirm Email:
HTML
INside Edge
Morning Briefing
BigWigs & New Gigs
Life Sciences Indiana
Indiana Connections
INPower
Subscribe
Unsubscribe

Events



  • Most Popular Stories

    • Niche ranked West Lafayette Schools as best in the state

      Dept. of Ed Releases School Accountability Grades

      The Indiana Department of Education has unveiled the school accountability grades for the 2017-2018 academic year. The department says about 22 percent of schools improved one or more letter grades, with 64 percent receiving an A or B.

    • Purdue Launches "Brain Gain" Initiative

      Purdue University wants to make Indiana the country's biggest "brain gain" state with a new initiative designed to bring Purdue grads back to Indiana companies. President Mitch Daniels says the pilot phase of the Purdue Brain Gain Initiative has piqued the interest of some 200 alumni, with a small number currently in the final interview process with employers in the state. Daniels told Inside INdiana Business...

    • Noblesville Approves $31M Development

      A Carmel-based developer is planning a $31 million project in Noblesville. The Noblesville Common Council has approved the effort from Jackson Development LLC, which calls for a 22-acre business park and 16-acre commercial and retail area. According to documents filed with the city, the developer is looking to build 200,000 square feet of office/flex buildings in what will be known as the Campus Center Business Park. The project will also feature...

    • (Image courtesy of JA of Central Indiana.) From left to right: Mark Shaffer, Tiffany Sauder, Blake Koriath, Chad Amos, Matt Waggoner, George Giltner, Erin Dettwiler, Cynthia Carrasco, Tiffany Fletcher, Kiamesha-Sylvia Colom, Tamara Cypress, Jennifer Burk

      'Best And Brightest' Earn Honors

      Winners of Junior Achievement of Central Indiana's 2018 Indy’s Best and Brightest awards have been announced. They include honorees who are 40 and under and recognized as "rising talent and the next generation of leaders in our community." Junior Achievement of Central Indiana Inc. focuses on educating and inspiring youth in career exploration, employability/life skills, entrepreneurship, financial literacy and philanthropy. It involves hands-on, experiential learning...
    • The auction runs through Friday.

      Medical Society Auctioning Off 'History'

      The Indianapolis Medical Society is this week auctioning off what it calls pieces of Indiana history as it prepares to move to smaller offices. The more than 150-year-old organization says items range from a clock made with wood dating back thousands of years to artifacts and historic documents. The Indianapolis Medical Society was established in 1848. The professional membership organization represents doctors of medicine and osteopathy in the Indianapolis area.