Study: Indiana Amish Gene Mutation Shows Longer Life Potential

Posted: Updated:
INDIANAPOLIS -

Northeast Indiana's Amish population is at the center of research that could help people live longer. Results from a 2015 study that were published late last year in the journal ScienceAdvances suggests those who possess a specific gene mutation, first identified in 1991 by the Indiana Hemophilia and Thrombosis Center in an Adams County girl with a rare bleeding disorder, live around a decade longer than normal. They also had lower insulin levels and diabetes rates. IHTC Pediatric Hematologist Sweta Gupta discussed the findings and the timeline for what's next during an interview with Barbara Lewis on Inside INdiana Business with Gerry Dick.

The study was a collaboration that involved Northwestern University and researchers from the IHTC.

"The next steps here are to figure out if we can target the PAI-1 protein to lower it down, so that human beings can lead a healthier and longer life," Gupta told Barbara Lewis in the Business of Health. "Studies are actually ongoing to develop an oral agent in Japan -- in Tohoku University -- where phase one trials are completed, phase two are almost done, and we are hoping that these clinical trials will take off in the U.S. so that these results can be translated into bigger discoveries." She is hopeful that sometime within the next couple of years or next decade advances will be made through the efforts.

The study involved 177 members of the Berne Amish community, 43 of which carried the mutation.

  • Perspectives

    • Do You Make These Top 5 Marketing Mistakes?

      Picture this: You’re the CEO of a multi-million dollar company. In just a few short years, you have led your firm in quickly become a rising star within your industry. Now, you’re ready to make your entrance into the big leagues known at this year’s premier tradeshow. The only problem is that your rapid growth has outpaced your "DIY" marketing. And to be taken seriously at the next level, your company needs a strong marketing message that clearly...

    More

Subscribe

Name:
Company Name:
Email:
Confirm Email:
HTML
INside Edge
Morning Briefing
BigWigs & New Gigs
Life Sciences Indiana
Indiana Connections
INPower
Subscribe
Unsubscribe

Events



  • Most Popular Stories

    • French Lick Resort Details $17M Expansion

      French Lick Resort has announced plans for a $17 million expansion project. The Orange County venue says construction has already begun on a six-story guestroom addition and new sports bar, which is expected to be complete in the fall of 2019. The project will add 56 guestrooms to French Lick, bringing the total number of rooms to 742 between the resort's two hotels. Both parts of the project, which will total more than 54,000 square feet, are being built near French Lick Casino.

    • Thor Set to Become Largest RV Maker in The World

      Elkhart-based Thor Industries Inc. (NYSE: THO) has announced an agreement to acquire a German recreational vehicle manufacturer for approximately $2.4 billion. Once complete, Thor says the deal for Erwin Hymer Group SE will create the world's largest RV maker. EHG currently employs more than 7,300 globally and its RVs are sold through a network of over 1,200 retailers. The companies say they expect no change in employee headcount or number of facilities as a result of...

    • Sigstr Locks Down $4M in Funding

      The head of an Indianapolis marketing tech company that has secured another multi-million dollar round of funding says there are multiple benefits to its location in the Hoosier State. Email signature and relationship marketing platform Sigstr has landed $4 million from investors led by New Jersey-based Edison Partners. Chief Executive Officer Bryan Wade attributes Sigstr's rapid upward trajectory to factors including...

    • TRIMEDX to Acquire Healthcare Technologies Business

      Indianapolis-based TRIMEDX has announced plans to acquire the healthcare technologies division of Philadelphia-based Aramark (NYSE: ARMK). The clinical engineering services company says the $300 million deal will allow it to deliver its services to a broader set of healthcare providers.

    • Do You Make These Top 5 Marketing Mistakes?

      Picture this: You’re the CEO of a multi-million dollar company. In just a few short years, you have led your firm in quickly become a rising star within your industry. Now, you’re ready to make your entrance into the big leagues known at this year’s premier tradeshow. The only problem is that your rapid growth has outpaced your "DIY" marketing. And to be taken seriously at the next level, your company needs a strong marketing message that clearly...