WEBVTT

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AS THE NEED FOR INSULIN GREW,

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THERE WAS DEMAND WOULD OUTSTRIP

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SUPPLY. THE

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SOLUTION WAS CREATED IN

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LABORATORIES IN THE MID 1980S BY

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SCIENTISTS USING GENETIC

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ENGINEERING TO CREATE SYNTHETIC

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INSULIN.

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LIFE-SAVING INNOVATION CREATED

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BY SCIENTISTS AT ELI LILLY AND

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COMPANY IN

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INDIANAPOLIS.

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LILLY'S LEGACY IN PIONEERING

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INSULIN IS WELL KNOWN IN INDIANA

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AND AROUND THE GLOBE

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AND THIS WEEKEND MARKS THE 40TH

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ANNIVERSARY OF A MAJOR

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BREAKTHROUGH AT LILLY THAT

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MADE THE MEDICINE AVAILABLE FOR

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MILLIONS. BUSINESS OF HEALTH

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REPORTER KYLIE VELETA

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IS HERE WITH MORE...

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THIS WEEKEND MARKS THE 40TH

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ANNIVERSARY OF HUMULIN, WHICH IS

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BIOSYNTHETIC

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INSULIN, BEING REGISTERED FOR

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HUMAN USE RIGHT HERE IN INDIANA.

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BIOSYNTHETIC MEANS IT WAS

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PRODUCED IN A LAB, RATHER THAN

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FROM NATURAL SOURCES, SUCH

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AS ANIMALS.

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PRIOR TO THIS BREAKTHROUGH,

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THERE WAS A RISK THAT INSULIN

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WOULD BECOME SCARCE, OR

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EVEN NEED TO BE RATIONED. THE

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MEDICINE MARKED A SHIFT TO A

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VIRTUALLY UNLIMITED

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SUPPLY OF INSULIN.

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HUMULIN WAS ALSO THE FIRST

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BIOSYNTHETIC MEDICINE FOR HUMAN

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USE...NOT JUST FOR

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DIABETES, BUT FOR ANY DISEASE.

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MILLIONS OF PATIENTS WITH

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DIABETES NOW RELY ON IT FOR

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DAILY USE.

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INDIANA'S OWN DR. RICHARD

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DIMARCHI, A SERIAL ENTREPRENEUR

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AND WORLD-RENOWNED

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CHEMIST, WAS A MAJOR CONTRIBUTOR

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TO THE PROJECT AS A SCIENTIST AT

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LILLY.

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HE SAYS THIS BREAKTHROUGH 40

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YEARS AGO IS RESPONSIBLE FOR

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TENS OF BILLIONS OF DOLLARS

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IN REVENUES, AND THOUSANDS OF

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HOOSIERS BEING EMPLOYED IN

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CENTRAL INDIANA.

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THE FACT THAT THIS WAS THE

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MODEL THAT SAID

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VENTURE CAPITALISTS COULD PUT

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THEIR MONEY TO WORK AND RECEIVE

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A HANDSOME RETURN AS

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LILLY WENT ABOUT VALIDATING THE

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TECHNOLOGY THAT CAME FROM THE

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UNIVERSITY, THROUGH

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GEN AND TECH, TO PATIENTS.

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SO THIS RECRUITED ADDITIONAL

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VENTURE CAPITAL TO GO INTO THIS

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EMERGING BIOTECH SECTOR.

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AND THE BIOTECH SECTOR HAS GROWN

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TO BE THE LEADING EDGE OF THE

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PHARMACEUTICAL

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INDUSTRY. SO WHEN YOU LOOK AT

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LILLY'S LATEST PRODUCTS, THINGS

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LIKE TRULICITY, AND

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MONJARO, THESE ARE COMPOUNDS

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THAT ARE BUILT WITH COMPARABLE

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BIOTECHNOLOGIES.

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DIMARCHI SAYS HUMULIN WAS THE

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FIRST TO SHOW THIS SAME

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TECHNOLOGY COULD BE USED

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TO PRODUCE POWERFUL HUMAN

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MEDICINE.

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ANISESSING STORY.

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>> HE'S A HUGE CHAMPION OF LIFE

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SCIENCES INDND.

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HE STARTED SIX COMPANIES.

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FIVE OF WHICH HAVE SUCCESSFULLY

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EXITED.

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ONE OF THEM SOLD FOR

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$300 MILLION.

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THE SIXTH ONE HE'S LEADING RIGHT

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NOW IS WELL ON ITS WAY TO HAVING

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A VERY SUCCESSFUL EXIT.

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>> INTERESTING.

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ALSO QUICKLY.

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I KNOW HE BELIEVES BIO TECH

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DIDN'T START IN SAN FRANCISCO,

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IT'S HERE IF INDIANA.

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>> WHICH SURPRISES A LOT OF

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PEOPLE.

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MOST PEOPLE ASSUME IT WAS BORN

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IN SAN FRANCISCO OR BOSTON.

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IT'S SO IMPORTANT FOR HOOSIERS

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TO KNOW IT WAS BORN HERE.

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IT'S HAD HUGE COMMERCIAL

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SIGNIFICANCE OVER THE YEARS.

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IT WAS THE START REALLY THE

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BIRTH OF INDIANA'S LIFE SCIENCES