WEBVTT 1 00:00:00.000 --> 00:00:04.704 >>GERRY: A TORN ROTATOR CUFF IS A VERY COMMON SHOULDER PROBLEM IN THE U.S., WITH MORE THAN 5 MILLION DOCTOR VISITS EACH YEAR 2 00:00:04.704 --> 00:00:12.445 RELATED TO THE INJURY. A NEW OPTION TO SURGICALLY REPAIR THE TORN TENDON IS NOW ON THE MARKET, CREATED BY TWO 3 00:00:12.445 --> 00:00:20.153 BOILERMAKER ENGINEERS WHO SAY IT COULD CUT RECOVERY TIME IN HALF. BUSINESS OF HEALTH REPORTER KYLIE VELETA HAS MORE... 4 00:00:20.153 --> 00:00:27.460 >>KYLIE: A SURGEON IN CHICAGO IS THE FIRST IN THE COUNTRY TO BEGIN USING THE NEW TISSUE IMPLANT, WHICH WAS DEVELOPED 5 00:00:27.460 --> 00:00:34.501 ENTIRELY AT PURDUE UNIVERSITY. AND IT'S LIKELY MORE PATIENTS WILL SOON HAVE THIS NEW OPTION. SPARTA BIOPHARMA, A PRIVATE 6 00:00:34.501 --> 00:00:38.571 COMPANY ON THE EAST COAST, IS NOW MARKETING THE TECHNOLOGY TO ORTHOPEDIC SURGEONS THROUGHOUT THE U.S. 7 00:00:38.571 --> 00:00:45.478 HERE TO TELL US MORE ABOUT THE PRODUCT, CALLED BIOENTHESIS, ARE TWO OF THE GREAT MINDS BEHIND ITS CREATION, DR. ERIC NAUMAN, A 8 00:00:45.478 --> 00:00:52.385 PROFESSOR OF MECHANICAL AND BIOMEDICAL ENGINEERING AT PURDUE AND DR. DARRYL DICKERSON, ASSISTANT PROFESSOR OF 9 00:00:52.385 --> 00:01:02.162 MECHANICAL AND MATERIALS ENGINEERING, FLORIDA INTERNATIONAL UNIVERSITY. THANK YOU BOTH FOR BEING ON THE 10 00:01:02.162 --> 00:01:06.833 SHOW TODAY. >> ABSOLUTELY. THANKS FOR HAVING US. >> WE SHOULD MENTION RIGHT OFF 11 00:01:06.833 --> 00:01:17.644 THE TOP YOU ARE IN FLORIDA, BUT WERE AT PURDUE WHEN THE PRODUCT WAS DEVELOPED SO GIVE US FIRST A QUICK EXPLANATION OF WHAT A TORN 12 00:01:17.644 --> 00:01:25.452 ROTATOR CUFF IS AND HOW IT'S TYPICALLY REPAIRED. >> THE ROTATOR CUFF IS A SERIES OF MUSCLES AND TENDONS I KEEP 13 00:01:25.452 --> 00:01:36.196 YOUR SHOULDER IN PLACE AND ALLOW MOTION TO OCCUR AND A TEAR IS ONE THAT TENDONS AND LIGAMENTS BECOME DAMAGED AND THAT COULD BE 14 00:01:36.196 --> 00:01:45.472 EITHER OVER TIME SO A LITTLE BIT THAT LEADS TO EVENTUAL DEGENERATION OR SOMETHING THAT IS SUDDEN AND WHAT DOCTORS TRIED 15 00:01:45.472 --> 00:01:55.215 TO DO IS REPAIR THAT STRUCTURE SO YOU HAVE THE STABILITY IN YOUR SHOULDER AND SOME MOBILITY AND WHEN THAT OCCURS YOU MOVE 16 00:01:55.215 --> 00:02:03.990 REMOVE THE DAMAGED TISSUES AND DOCTORS WILL TRY TO REATTACH THE REST OF THE HEALTHY TISSUE TO THE UNDERLYING AREA. 17 00:02:03.990 --> 00:02:12.465 >> VERY GOOD. SO ERIC, THIS NEW TECHNOLOGY YOU CREATED AT PURDUE IS NOW ON THE MARKET CALLED BIOENTHESIS A 18 00:02:12.465 --> 00:02:18.771 TISSUE IMPLANT. EXPLAIN WHAT IT IS AND HOW IT WORKS. >> IT IS BASICALLY THERE TO 19 00:02:18.771 --> 00:02:28.047 REPAIR THE INTERFACE BETWEEN THE ESSENTIALLY RIGHT NOW SURGEONS PRESS THEM TOGETHER AND HOPE THAT IT GROWS IN. 20 00:02:28.047 --> 00:02:38.324 WHAT WE DO IS WE GRIND DOWN THAT TOP LAYER OF DENSE BONE AND EXPOSE THE MARROW AND THE ADULT STEM CELLS JUST BELOW THE 21 00:02:38.324 --> 00:02:49.135 SURFACE AND THEN WE REPLACE THAT BONE THAT WE GROUND AWAY WITH A POROUS SCAFFOLD AND IT'S A POROUS SCAFFOLD AND IT'S MADE 22 00:02:49.135 --> 00:02:58.711 OUT OF SPONGY BONE THAT YOU FIND THROUGHOUT THE BODY. WHEN YOU PRESS IT IN THE ADULT STEM CELLS INVADE. 23 00:02:58.711 --> 00:03:10.557 THEY KNOW TO MAKE BONE AND WE DEMINERALIZED THE TOP LAYER SO THAT THE STEM CELLS KNOW THAT'S WHERE THEY ARE SUPPOSED TO FORM 24 00:03:10.557 --> 00:03:18.965 COLLAGEN AND BY PRESSING THE DAMAGED TENDON AGAINST THAT YOU ESSENTIALLY GET THEM TO REGROW THE ENTIRE YEAR JOINT SURFACE 25 00:03:18.965 --> 00:03:31.744 AND THEN YOU END UP BECAUSE THE BIOENTHESIS IS A SINGLE ENTITY YOU END UP WITH A NICE RE- GROWN INTERFACE THAT TAKES YOU FROM 26 00:03:31.744 --> 00:03:40.320 TENDON AND CARTLEDGE TO BONE. >> TALK JUST A LITTLE BIT MORE ABOUT THE BENEFITS OF THE TISSUE IMPLANT HOW IT IS BETTER THAN 27 00:03:40.320 --> 00:03:53.166 CONVENTIONAL METHODS? >> ERIC EXPLAINED IT VERY WELL SO TENDONS IN THE BODY ARE ELASTIC TISSUES IN THE BONE IS 28 00:03:53.166 --> 00:04:01.908 VERY HARD. IT CAN BE A HUNDRED TIMES DIFFERS SOMEWHAT THE TENDON IS SO YOU NEED THE STRUCTURE TO 29 00:04:01.908 --> 00:04:14.621 ENSURE THAT IT WORKS WELL AND SO NATURALLY YOU HAVE A GRADUAL TRANSITION GOING FROM THE TENDON TO THE BONE AND WHAT THIS NEW 30 00:04:14.621 --> 00:04:24.564 IMPLANT DOES IS HELPS THE BODY TO REGROW THAT AND INSTRUCTS THE BODY TO REPAIR THAT AND SOMEWHERE IN THE RANGE OF 31 00:04:24.564 --> 00:04:34.340 90 PERCENT OF REPAIRS CAN FAIL SO WE THINK THAT WITH THIS STRUCTURE REPAIRING THE NORMAL STRUCTURE OF THE TENDON AND BONE 32 00:04:34.340 --> 00:04:41.914 INTERFACE AND WE SEE THAT REDUCE QUITE A BIT. >> YOU MENTIONED EARLIER YOU CUT THE RECOVERY TIME IN HALF WHICH 33 00:04:41.914 --> 00:04:49.922 IS IMPRESSIVE. THIS WHOLE IDEA OF FOCUSING ON THIS POINT WHERE BONE AND MUSCLE MEAT HOW DOES THAT OPEN THE DOOR 34 00:04:49.922 --> 00:04:57.797 TO SOME OTHER APPLICATIONS? COULD THIS BE DONE IN OTHER JOINTS IN THE BODY? >> CERTAINLY. 35 00:04:57.797 --> 00:05:05.438 THE INTERESTING THING HERE IS WHEN HE WAS A STUDENT HE DEVELOPED HIS OWN WAY OF REPAIRING THESE INTERFACES AND 36 00:05:05.438 --> 00:05:15.581 YOU HAVE THAT THROUGHOUT THE BODY AND EVERY MUSCLE ATTACHES INTO THE BONE AND LIGAMENTS ATTACH BONE TO BONE AND 37 00:05:15.581 --> 00:05:26.426 CARTLEDGE IS ONLY USEFUL BECAUSE IT ADHERES TO THE UNDERLYING BONE TISSUE AND WE LOOKED DOWN THE ROAD WE MIGHT BE ABLE TO 38 00:05:26.426 --> 00:05:38.838 REPAIR FOR ACL AND PCL AND GET PEOPLE WITH KNEE INJURIES FASTER REPAIRS AND THE UCL FOR BASEBALL PITCHERS AND ACHILLES IN THE 39 00:05:38.838 --> 00:05:45.144 NEWS LATELY BECAUSE IT'S A HUGE TENDON DIFFICULT TO REPAIR AND THAT SOMETHING WE GO AFTER, BUT PROBABLY THE CARTLEDGE INTERFACE 40 00:05:45.144 --> 00:05:54.854 HAS THE MOST PROMISE BECAUSE OSTEOARTHRITIS USUALLY STARTS AS A SMALL INJURY BUT THEN OVER TIME IT KIND OF JEERED -- 41 00:05:54.854 --> 00:06:01.794 DEGENERATES MORE AND MORE LEADING TO TOTAL JOINT REPLACEMENT. IF WE CAN LOOK AT THAT AND 42 00:06:01.794 --> 00:06:09.268 REPAIR THAT BEFORE THE INJURY SETS IN WE MIGHT BE ABLE TO STAVE OFF THE NEED FOR TOTAL JOINT REPAIRS. 43 00:06:09.268 --> 00:06:16.576 >> ONLY A COUPLE OF SECONDS LEFT, BUT TELL US QUICKLY HOW DID THE CONNECTION COME ABOUT WITH SPARTA BAYOU FORM A. 44 00:06:16.576 --> 00:06:28.321 NOW COMMERCIALIZING THIS. >> IT CAME ABOUT WE STARTED A COMPANY RIGHT AFTER MY DISSERTATION AND SPARTA CAME 45 00:06:28.321 --> 00:06:40.066 ALONG LOOKING FOR A PARTNER FOR A RANGE OF ACTIVITIES AND DECIDED THIS WAS THE RIGHT PARTNERSHIP OPPORTUNITY SO 46 00:06:40.066 --> 00:06:47.573 THEY'VE BEEN A GREAT COMMERCIALIZATION PARTNER FOR THIS AND WE HAVE APPLICATIONS AS WELL.