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>> THE ALZHEIMER'S ASSOCIATION
GREATER INDIANA CHAPTER IS
BACKING ITS MISSION BY MAKING
ITS LARGEST RESEARCH GRANT EVER.

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BUSINESS OF HEALTH REPORTER
KYLIE VELETA IS HERE TO EXPLAIN
HOW THE MONEY PUSHES A
PRESTIGIOUS I.U. SCHOOL OF

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MEDICNE STUDY TO THE NEXT
LEVEL.
KYLIE.
>> THAT'S RIGHT, GERRY.

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ABOUT ONE YEAR AGO, THE I.U.
SCHOOL OF MEDICINE LANDED ITS
LARGEST SINGLE GRANT FROM THE
NATIONAL INSTITUTES OF HEALTH.

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THE $45 MILLION AWARD TAPPED THE
UNIVERSITY TO LEAD A FIVE-YEAR
NATIONAL RESEARCH STUDY FOCUSED
ON THE YOUNGEST PATIENTS WITH

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ALZHEIMER'S.
THE PROJECT IS CALLED LEADS, AND
HERE TO TELL US ABOUT THE IMPACT
OF THE NEW ONE-MILLION-DOLLAR

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GIFT IS THE STUDY'S LEAD
RESEARCHER.
DR. LIANA APOSTOLOVA, A
PROFESSOR AT THE I.U. SCHOOL OF

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MEDICINE, AND NATALIE SUTTON,
EXECUTIVE DIRECTOR OF THE
ALZHEIMER'S ASSOCIATION GREATER
INDIANA CHAPTER.

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THANK YOU BOTH FOR COMING TO THE
SHOW.
>> THANK YOU, KYLIE.
>> LET'S START WITH YOU AND THE

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LEADS PROGRAM.
IT FOCUSES ON EARLY ONSET
ALZHEIMER'S, WHICH IS ESPECIALLY
DEVASTATING FORM OF THE DISEASE.

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TELL US A LITTLE BIT ABOUT EARLY
ONSET, HOW IT IMPACTS PATIENTS
AND FAMILIES.
>> OF COURSE.

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WHAT WE KNOW ABOUT ALZHEIMER'S
IS REALLY ALL COMING FROM THE
LATE VERSION OF THE DISEASE,
WHICH IS 95% OF THOSE WHO ARE

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AFFECTED WITH ALZHEIMER'S.
ABOUT 5% OR 200 TO 300,000 IN
THE UNITED STATES, THOUGH, HAVE
AN EARLY ONSET FORM THAT IS

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THOSE THAT ARE LESS THAN 65
YEARS OLD.
THEY COULD BE AS YOUNG AS 40, AS
YOUNG AS 50.

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THEY COULD BE OUR AGE LADIES,
AND GUESS WHAT, THESE PEOPLE ARE
STILL IN THE WORKFORCE, THEY'RE
NOT READY TO RETIRE, THEY'RE

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RAISING CHILDREN OR SUPPORTING
THEM THROUGH COLLEGE, AND THEY
DON'T HAVE ANY LONG TERM PLANS,
INSURANCE SET IN MOTION TO BE

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ABLE TO TAKE TIME OFF WORK, LET
ALONE GO ON DISABILITY.
SO IT IS A TREMENDOUS IMPACT FOR
THE FAMILY.

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>> NATALIE, LET'S TALK ABOUT THE
$1 MILLION GRANT THAT YOUR
ORGANIZATION IS PROVIDING THE
STUDY AND HOW IT REALLY KICKS IT

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UP A NOTCH.
>> IT REALLY DOES.
THE NIH FUNDING OBVIOUSLY IS
SIGNIFICANT AND ALLOWS DATA

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COLLECTION FROM ALL OVER THE
COUNTRY FOR THE STUDY, BUT THE
INITIAL NIH FUNDING ONLY FUNDED
RESEARCHERS TO LOOK AT ABOUT 2%

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OF THE GENOME.
SO OUR $1 MILLION GRANT IS GOING
TO ENABLE THE RESEARCHERS TO
STUDY THE ENTIRE GENOME OF ALL

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600 PATIENTS ACROSS THE COUNTRY,
AND WE BELIEVE THERE MIGHT BE
SOME UNDERLYING RISK FACTORS
THAT WE COULD UNCOVER BY LOOKING

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AT THE ENTIRE GENOME IN THESE
PATIENTS.
>> SO DR. APOSTOLO VA, YOU'RE
FOCUSING ON EARLY ONSET BUT DO

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YOU LEARN MORE ABOUT ALZHEIMER'S
DISEASE IN GENERAL?
>> ESPECIALLY THE GENETICS
PORTION OF IT, WE KNOW MAYBE 30,

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40 RISK FACTORS FOR THE LATE
ONSET VERSION OF THE DISEASE BUT
STILL SO MUCH OF THAT GENETIC
RIGGS BEING IS

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RISK IS MISSING.
WE SEE THAT IN FAMILIES WHERE
ALZHEIMER'S DISEASE HAS HIT,
THAT THESE INDIVIDUALS, THEIR

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CHILDREN, THEIR SIBLINGS ARE
MORE LIKELY TO DEVELOP
ALZHEIMER'S, AND WE NEED TO KNOW
MORE ABOUT WHAT CAUSES THIS

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RISK.
AND BY STUDYING EARLY ONSET, WE
WILL BE ABLE TO SEE THE MOST
AGGRESSIVE GENES THAT WE HAVE

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NOT DISCOVERED SIMPLY BECAUSE WE
HAVE NOT LOOKED AT PATIENTS THIS
YOUNG.
SO THESE WOULD BE IMPORTANT

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DISCOVERIES FOR ALL OF
ALZHEIMER'S, AND WOULD ALSO LEAD
TO DOWNSTREAM RESEARCH THAT WILL
ALLOW US TO STUDY DISEASE

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MECHANISMS AND TO UNCOVER NEW
THERAPEUTIC TARGETS.
>> SO NATALIE, EARLY ONSET,
BECAUSE IT'S RARE, IS IT LESS

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STUDIED AND DID THAT HELP THE
ORGANIZATION DECIDE HOW TO
DIRECT ITS DOLLARS?
>> ABSOLUTELY.

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THIS GROUP OF PATIENTS HAS
REALLY NOT BEEN STUDIED BY OTHER
RESEARCH IN THE PAST, SO MUCH OF
THE EARLY ONSET RESEARCH HAS

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FOCUSED ON THE FAMILIAL FORM OF
THE DISEASE, AND AT THE
ALZHEIMER'S ASSOCIATION, WE'RE
LOOKING AT THE ENTIRE SCOPE OF

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RESEARCH.
WE'RE REALLY PLEASED THAT OUR
ORGANIZATION NATIONALLY HAS BEEN
BEHIND THE STUDY FROM THE

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BEGINNING, BUT ALSO REALLY PROUD
HERE IN INDIANA THAT THIS
IMPORTANT RESEARCH IN THE FIELD
IS TAKING PLACE IN OUR BACKYARD,

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SO IT WAS A GREAT OPPORTUNITY
FOR OUR LOCAL BOARD OF DIRECTORS
TO SUPPORT THIS WORK.
>> AND SPEAKING OF RESEARCH

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TAKING PLACE HERE, HOOSIERS ARE
INVOLVED.
TELL US HOW WE CAN GET MORE
INVOLVED.

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>> WELL, WE'RE STILL RECRUITING.
SO WE'RE LOOKING FOR INDIVIDUALS
WHO ARE COGNITIVELY IMPAIRED
BETWEEN THE AGES OF 40 AND 64 AT

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15 LOCATIONS ACROSS THE NATION,
AND OF COURSE IN INDIANA.
SO IF THERE IS ANYONE THAT --
ANYONE KNOWS, PLEASE CALL US,

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CALL INDIANA UNIVERSITY AND
VISIT US AT THE WEBSITE,
WWW.LEADS-STUDY.ORG.
>> GREAT WORK TAKING PLACE RIGHT

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HERE IN INDIANA, INDIANAPOLIS.
THANK YOU BOTH FOR BEING HERE
TODAY.
>> THANK YOU.

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GERRY, BACK TO YOU.
>> KYLIE, THANK YOU.
ALSO THIS WEEK, INDIANA RANKS
NEAR THE BOTTOM OF THE LIST WHEN

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IT COMES TO HOW MUCH FEDERAL
FUNDING IT RECEIVES TO FIGHT THE
OPIOID EPIDEMIC.
THE INDIANAPOLIS-BASED RICHARD

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M. FAIRBANKS FOUNDATION'S
RELEASED A REPORT, WHICH
COMPARES THE AMOUNT OF FUNDING
EACH STATE HAS RECEIVED TO ITS

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PERCENTAGE OF OPIOID-RELATED
OVERDOSE DEATHS.
THE REPORT SAYS INDIANA RECEIVED
NEARLY $160 MILLION BUT WAS

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STILL UNDERFUNDED BY MORE THAN