IU School of Medicine Report Targets Breast Cancer

Posted: Updated:
INDIANAPOLIS -

A new report from the Vera Bradley Foundation Center for Breast Cancer Research at the Indiana University School of Medicine outlines potential future options to treat triple negative breast cancer. Researcher Xiongbin Lu says he and a collaborator have patented a new "nano-bomb" method, which could lead to a targeted therapy option.

Unlike the three most common forms of breast cancer, triple negative breast cancer has no currently approved targeted therapies for treatment.

According to the report, TP53 is the most frequently mutated gene in triple negative breast cancer, meaning it is a catalyst to the growth of this aggressive form of breast cancer. 

However, targeting mutated TP53 genes was not viable because of its ability to kill nearby healthy cells. Lu and his team were able to identify a neighboring gene to TP53, known as POLR2A, which is a viable target for the analysis.

They were able to create what they are calling a "nano-bomb.” The bomb is made in a form that is stable in serum and grows to 100 times its normal size through a controlled release, killing only the cancerous cell and leaving the healthy cells alive. 

Lu and a collaborator have patented the nanotechnology "nano-bomb" method, which also has potential implications in other cancers that display the mutated TP53 gene, such as ovarian, lung and colorectal cancer. 

“We’re still in the early stages of research, but I am excited about this approach and its potential to lead to a targeted therapy option for women with triple negative breast cancer,” Lu said in a news release.

To read the full study, click here. 

  • Perspectives

    • (photo courtesy of Conexus)

      October Celebrates Indiana’s Vibrant Manufacturing Industry

      Indiana is the most manufacturing intensive state in the country and more than a third of the state’s GDP comes from the industry. The health and wellness of Indiana’s economy is dependent on the state’s manufacturing industry. But Hoosiers face a challenge: it is expected that nearly a quarter of the current manufacturing workforce will be of retirement age in the next 10 years and we lack the generational workforce to make up that gap.

    More

Subscribe

Name:
Company Name:
Email:
Confirm Email:
HTML
INside Edge
Morning Briefing
BigWigs & New Gigs
Life Sciences Indiana
Indiana Connections
INPower
Subscribe
Unsubscribe

Events



  • Most Popular Stories

    • Regal Beloit is closing in Valparaiso. (photo courtesy; The Times of Northwest Indiana)

      Valpo Bearings Plant to Close, Eliminating 160+ Jobs

      Wisconsin-based Regal Beloit Corp. and the union representing workers have reached an agreement about the closing of a helicopter bearing factory in Valparaiso. According to our partners at The Times of Northwest Indiana, the decision will cost between 160 to 170 workers their jobs. 

    • (image courtesy of The Times of Northwest Indiana)

      U.S. Steel Updates Layoff Notice to State

      Pittsburgh-based U.S. Steel Corp. (NYSE: X) has updated the State of Indiana regarding its previously announced layoffs at the East Chicago Tin Mill. The company says 314, rather than 307, workers will be displaced when the mill is idled this fall. 

    • The Columbian Home Products plant was built in Terre Haute in 1902.

      Kitchenware Maker to Close in Terre Haute

      Illinois-based Columbian Home Products LLC has sent a letter to the State of Indiana saying it intends to close its plant in Terre Haute and lay off 82 workers. According to the WARN letter sent to the Indiana Department of Workforce Development, the layoffs will begin on December 1. 

    • The Lawn at White River State Park currently hosts concerts, but is not a permanent venue. (photo courtesy White River State Park)

      White River Park to Break Ground on Permanent Venue

      White River State Park in Indianapolis will Wednesday host a ground-breaking ceremony for a permanent concert venue on its concert lawn. The project, announced early last year, will include a permanent st...

    • Ingram Micro has more than 170 facilities throughout the world.

      Ingram Micro to Make Announcement

      Officials in Plainfield are set to make another economic development announcement Wednesday morning. Few details are available, however the Indiana Economic Development Corp. says executives from California-based Ingram Micro will take part in the announcement.