IU Med School in on $25M Alzheimer's Initiative

Posted: Updated:
Bruce Lamb (pictured) and Paul Territo at IU School of Medicine will jointly lead the center with Gareth Howell and Greg Carter from JAX. Bruce Lamb (pictured) and Paul Territo at IU School of Medicine will jointly lead the center with Gareth Howell and Greg Carter from JAX.
INDIANAPOLIS and BARR HARBOR, Maine -

Indiana University is part of a five-year, $25 million effort to help push through a "bottleneck" of new treatments for Alzheimer's disease. The funding from the National Institute of Aging will support the new Alzheimer's Disease Precision Models Center at the IU School of Medicine in Indianapolis and the globally-recognized Jackson Laboratory in Maine.

The condition is one of the top six causes of death in the U.S., affecting an estimated five million people. IU says the center will aim to create dozens of new Alzheimer's disease models, as well as study physiology, behavior and disease relevance and ultimately, discover and test potential treatments for the disease.

IU says success rates to date for clinical trials following testing in animals have been "disappointing." Gareth Howell from Jackson Laboratory, who will co-lead the center with Greg Carter from JAX and IUSM's Bruce Lamb and Paul Territo, says "existing mouse models for Alzheimer's disease have provided important insights into aspects of Alzheimer's disease biology, but have not been great preclinical models as they do not sufficiently model the disease. Our aim is to develop animal models that more closely mimic human Alzheimer's disease and a preclinical testing pipeline through which novel therapies can be tested to greatly accelerate the process by which therapies are successfully moved forward to human Alzheimer's disease clinical trials."

Lamb is executive director of the Stark Neurosciences Research Institute at IU School of Medicine and says many genetic variants linked to the disease, but with unknown roles have been identified over the last decade. "Developing these new animal models will be key to ultimately translating those research discoveries into new Alzheimer's therapies," he said. "The goal of this partnership is to create animal models that will, on a national level, accelerate the development of effective therapies for Alzheimer’s disease."

The partners say the collaboration will build on existing strengths like IU's NIA-supported Indiana Alzheimer Disease Center, expertise in clinical drug testing and a role in the national Alzheimer's Disease Neuroimaging Initiative. JAX is home to the NIA-supported Nathan A. Shock Center of Excellence in the Basic Biology of Aging and has worked in mammalian genetics and disease modeling for more than 80 years. The organization also provides mouse and data resources to the international biomedical research community.

The team will also include contributions from Michael Sasner and Stacey Rizzo from JAX, and Sage Bionetworks will distribute results from the initiative.

You can connect more on the center by clicking here.

  • Perspectives

    • 90 Minutes by 2020

      Chicago is the third-biggest city in the United States and more than ten million people live in the Chicagoland metropolitan area. Another seventy-six million people visit the area each year. Chicago is an international hub for commerce, and is a leader in industries like finance, manufacturing, technology, and telecommunications. It boasts the second busiest airport in the world and has one of the largest, most diversified economies in the world.

    More

Events



  • Most Popular Stories

    • Cummins Expanding Indiana Wind Farm

      Columbus-based Cummins Inc. (NYSE: CMI) is expanding a wind farm in northern Indiana. The company says, when fully operational, the farm will generate renewable energy equal to the amount Cummins uses at its Indiana facilities. The expansion will add 75 megawatts of capability to the plant, which is enough to power about 20,000 average Indiana homes. The Meadow Lake Wind Farm complex currently has a capacity of 600 megawatts.

    • On-Air

      Find out when and where you can watch and listen to our reports.

    • Busche Owner Makes Another Acquisition

      Albion-based Busche Performance Group Inc. says its parent company has acquired Michigan-based 3Point Machine Inc. Shipston Equity Holdings LLC, based in New Hampshire, says 3Point will be called Busche Performance Group Southfield Inc. as a result of the merger. 

    • Indiana Is Lifting the Future of Flight

      While on the floor of the Farnborough International Airshow, the world’s largest exhibition dedicated to the aviation industry, it was clear to international industry leaders that Indiana is propelling the future of aerospace and aviation. That’s because, from the unveiling of a new flight technology to the top companies exhibiting at the airshow, everything seemed to keep coming back to Indiana.

    • Saint Joseph's Students, Faculty Scrambling

      Two days after the Saint Joseph's College Board of Trustees voted to suspend activities on the Rensselaer campus, students and faculty are searching for answers. A source with close knowledge of the situation tells Inside INdiana Business one of the issues that led to the school's "dire" financial situation is a trust involving land some say is worth up to $75 million, but would only be able to sell for $15 million because of restrictions in place.